Diabetes mellitus is a common metabolic disorder with severe complications and the population suffering from this disease has been increasing. It has been noted that oxidative stress conditions in the body are correlated with impairment of blood glucose regulation.
In particular, findings suggest to us that oxidative stress in pancreatic islets plays an important role in the cause and/or progression of diabetes mellitus. Indeed, hyperglycemia-mediated oxidative stress appears to be involved in various diabetic complications and is actually increased in diabetes patients. Thus, the roles played by Nrf2 in the pathogenesis (cause) of diabetes mellitus and in the development of its complications have emerged as important research topics.
http://diabetes.diabetesjournals.org/content/60/11/2683.full
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