MAKE, NOT TAKE-How your body can protect itself from cellular stress.

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At the very center of our cellular protective pathway is a protein called “Nrf2” that serves as a “master regulator” of the body’s antioxidant response. You might think of Nrf2 as a “thermostat” within our cells that senses the level of oxidative stress and other stressors and turns on internal protective mechanisms.

Soon after Nrf2 was identified, a flurry of scientific discoveries began to show how Nrf2 also regulated genes involved in the production of a wide range of antioxidant enzymes (including SOD, glutathione, and catalase), and detoxification or ‘‘stress-response’’ genes. These protective pathways are involved in seemingly unrelated areas of health from immune function to tissue optimization to cognitive function – but they all share in common the Nrf2 “switch” that enables cells to protect themselves from both internal and external environmental challenges. In effect, Nrf2 activation enables our cells to make their own antioxidants to help us survive – and thrive – in stressful situations.


How does Nrf2 work?

When activated, Nrf2 turns on the production of specific antioxidants the body needs to fight cellular stress effectively. Certain phytochemicals (turmeric, ashwagandha, bacopa, green tea, and milk thistle) synergistically activate Nrf2. Turning on Nrf2 creates a cascading effect that results in the production of several very powerful antioxidants. These antioxidants do a much better job at combating cellular stress than dietary, vitamin or phytochemical source individually. Several antioxidant enzymes, including superoxide dismutase (SOD), glutathione, and catalase are activated through the Nrf2 pathway. Many scientists believe that Nrf2 activation is the “future” of cellular protection and health promotion, this foundation of naturally activating Nrf2 to “solve” the problem of cellular stress is a fundamentally different way of restoring balance in the body.

Nrf2 Pathway Is the Solution to Better Health and Performance

At present, it appears that all forms of exercise, both aerobic and anaerobic, possess the potential to result in increased cellular stress in both human and animal models.  Several factors appear to play a significant role in the exercise-induced cellular stress response including duration and intensity of exercise, as well as the training status and dietary intake of the subject population.

In the past, the relationship between exercise and oxidative stress has commonly been viewed as a detrimental phenomenon that should be reduced or eliminated in an effort to improve performance and/or health. While cellular stress certainly has the ability to result in physiological damage, perhaps leading to the development of ill-health and/or disease over time, an optimal level of antioxidants produced in our bodies may increase our defenses.

ANTIOXIDANT PILLS ARE NOT THE ANSWER!

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Could it be that the vitamin pills you think are protecting you are actually causing you harm by accelerating the aging process and even increasing cancer risk? In fact, a growing number of studies show that isolated, synthetic, high-dose antioxidant supplements—you know, the bottles of “multi” pills you get at the grocery store or even the health food store that contain vitamin E, selenium, and beta-carotene, among others—may have a dark and dangerous side.

We know that free radical damage is a real and growing menace to our bodies, threatening our cells, DNA, tissues and organs with inflammation and degradation and leading to a host of chronic diseases, including cancer, chronic fatigue, diabetes, arthritis, and heart disease. But there’s great news! Exciting new research is also demonstrating how the human body protects itself by turning on its own built-in and ultra-powerful antioxidant defense systems. Best-selling author and researcher Shawn Talbott, PhD, teaches the protective actions of the Nrf2 pathways and how they represent the true solution to less illness, better health, and an enhanced level of vitality and wellness you never thought possible! You can find out more at this site:  http://www.shawntalbott.com